|
KMID : 1123920110250020306
|
|
Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 2 p.306 ~ p.310
|
|
|
Effects of Albizziae Cortex Extracts on the Elastase Activity and DPPH and NO Scavenging Activities
|
|
Leem Kang-Hyun
|
|
|
Abstract
|
|
|
|
Elastic fibers are found in the skin, lungs, arteries, veins and other structures. Elastases destroy the elastic fibers and cause the emphysema and pulmonary hypertension. Oxidative stress is needed for these pathologic changes. Accordingly, present study was designed to investigate the effect of Albizziae Cortex extracts (ACE) on elastase activity and anti-oxidative effects of ACE. The in vitro inhibitory effects on elastase and di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) and nitric oxide (NO) free radical scavenging activities of ACE were measured. The elastase activity was significantly inhibited by ACE. DPPH and NO free radicals were significantly scavenged as well. ACE showed the elastase-inhibiting effects and anti-oxidative activities in vitro. These results suggest that ACE may have potential roles in the treatment of pulmonary emphysema and pulmonary hypertension.
|
|
|
KEYWORD
|
|
|
Albizziae Cortex, Albizzia julibrissin, elastase, DPPH, NO
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|